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Common information about the Harmless and efficient usage of Depakote Medicines are occasionally prescribed for reasons other than Those people shown within a Medication Guidebook. Do not use Depakote for your issue for which it was not prescribed.
Estrogen-Containing Hormonal Contraceptives Estrogen-that contains hormonal contraceptives may well enhance the clearance of valproate, which can bring about decreased concentration of valproate and probably enhanced seizure frequency.
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Consequently, healthcare providers who elect to more info utilize Depakote for extended periods ought to regularly reevaluate the lengthy-phrase usefulness in the drug for the individual affected person.
For prophylaxis of migraine headaches, Depakote is contraindicated in Women of all ages that are pregnant As well as in Females of childbearing possible who are not making use of effective contraception [see CONTRAINDICATIONS].
Dose reductions or discontinuation of valproate need to be thought of in people with lessened food items or fluid consumption and in individuals with excessive somnolence. The final word therapeutic dose need to be obtained on The idea of equally tolerability and clinical response [see WARNINGS AND Safety measures, Use In Distinct Populations, and Medical PHARMACOLOGY].
In epileptic patients Formerly obtaining valproic acid therapy, Depakote tablets should be initiated at the identical each day dose and dosing agenda. After the individual is stabilized on Depakote tablets, a dosing agenda of two or three times every day may very well be elected in selected sufferers.
Considering the fact that clients have been getting titrated off An additional antiepilepsy drug during the initially part of the trial, it can be not possible, in several situations, to determine whether or not the subsequent adverse reactions could be ascribed to Depakote alone, or The mixture of valproate as well as other antiepilepsy prescription drugs.
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For the reason that these reactions are described voluntarily from a population of unsure dimensions, It's not at all often possible to reliably estimate their frequency or set up a causal romantic relationship to drug publicity.